Figure 1.
High-fat diet aggravates spatial learning impairment in APP23 mice and T0901317 ameliorates the deficit: MWM acquisition test. A, Path length scores represent the average distance swum to find the platform per trial block. (1) There was a significant treatment effect on path length (F(2,41) = 10.52, p < 0.0001); (2) a treatment × trial block interaction significantly affects path length as well (F(8,164) = 2.59, p < 0.01). p < 0.05, ND-Veh compared to HF-Veh by Tukey's post hoc test. B, Escape latency scores represent the average acquisition time to find the platform per trial block. (1) There was a significant treatment effect on escape latency (F(2,41) = 18.34, p < 0.0001); (2) similar to the effect on the path length, treatment × trial block interaction significantly affects the escape latency (F(8,164) = 4.02, p < 0.0001). ND-Veh versus HF-Veh, p < 0.05 by Tukey's post hoc test. n = 14 APP23 mice per group. C, D, Path length (C) and acquisition time (D) in WT controls subjected to the same diets ± T0 do not show significant difference between the groups. n = 4–12 WT mice per group. Analysis was performed by RM-ANOVA followed by Tukey's post hoc test for multiple comparisons. All points represent means ± SEM.