Figure 5. Increased pNF-H caudal to the lesion following Ch'ase ABC treatment. Nonbiased stereological quantification of the area fraction of pNF-H (A) was assessed in four regions of the spinal cord: ipsilateral gray matter (B, C), contralateral gray matter (D, E), ipsilateral white matter (F, G), and contralateral white matter (H, I). The pNF-H-positive area was significantly greater in Ch'ase ABC-treated animals compared with controls in the contralateral gray matter (A; D, E; *p = 0.003) and ipsilateral white matter (A; F, G; *p = 0.033). There was no significant difference between groups in the ipsilateral gray matter (A; B, C) or contralateral white matter (A; H, I). Error bars denote SEM. Photomicrograph examples shown are from one Ch'ase ABC and one control cat. The dorsal horn (DH) and ventral horn (VH) are shown in the ipsilateral and contralateral gray matter examples (B–E). The ipsilateral and contralateral white matter (F–I) examples are from the lateral funiculus. Scale bar, 0.1 mm.