Author contributions: V.C.P., M.G.D.-S., M.S.E., and A.F.S. designed research; V.C.P., M.G.D.-S., M.S.E., L.A.M., and M.F.T. performed research; V.C.P., M.G.D.-S., M.S.E., L.A.M., M.F.T., and A.F.S. analyzed data; V.C.P. and A.F.S. wrote the paper.
↵*V.C.P., M.G.D.S., and M.S.E. contributed equally to this work.
- Received March 18, 2011.
- Accepted April 5, 2011.
This work was supported by the Guggenheim Foundation Fellowship and by Agencia Nacional para la Promoción de Ciencia y Tecnología Grant PICT2005, the American Health Assistance Foundation (Alzheimer's Disease Research Grant A2007-078), the Delfina Baratelli Foundation, and the Howard Hughes Medical Institute (International Scholars Program Grant 55005963) (A.F.S.). A.F.S. and L.A.M. are investigators of the Argentine National Research Council [Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)]. V.C.P., M.G.D.-S., and M.S.E. were supported by doctoral fellowships from CONICET. We thank Mariela Veggetti for technical assistance, and Guillermo Lanuza, Antonia Marín Burgin, and Laura Ewell for critical suggestions and for comments on this manuscript.
The authors declare no competing financial interests.
- Correspondence should be addressed to Alejandro F. Schinder, Laboratory of Neuronal Plasticity, Leloir Institute, Consejo Nacional de Investigaciones Científicas y Técnicas, Avenida Patricias Argentinas 435, 1405 Buenos Aires, Argentina.