Articles, Development/Plasticity/Repair

Nestin Is Not Essential for Development of the CNS But Required for Dispersion of Acetylcholine Receptor Clusters at the Area of Neuromuscular Junctions

Paria Mohseni, Hoon-Ki Sung, Amanda J. Murphy, Christine L. Laliberte, Hanna-Mari Pallari, Mark Henkelman, John Georgiou, Gang Xie, Susan E. Quaggin, Paul S. Thorner, John E. Eriksson and Andras Nagy
Journal of Neuroscience 10 August 2011, 31 (32) 11547-11552; DOI: https://doi.org/10.1523/JNEUROSCI.4396-10.2011

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  • Submitted on: (30 November 2018)
    RE: About the Nestin KO phenotype

    Greetings.
    I noticed an article published in the Stem Cells 1-year before this one, which also generated a Nestin-/- mouse line and reported a contradictory phenotype:
    Nestin Is Required for the Proper Self‐Renewal of Neural Stem Cells.
    https://doi.org/10.1002/stem.541

    I understand the detailed targeting sites of these two works were not the same.
    But I got confused about the role of Nestin during embryonic CNS development.
    Could you please explain a little bit?

    Thank you very much!

    Competing Interests: None declared.
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Nestin Is Not Essential for Development of the CNS But Required for Dispersion of Acetylcholine Receptor Clusters at the Area of Neuromuscular Junctions
Paria Mohseni, Hoon-Ki Sung, Amanda J. Murphy, Christine L. Laliberte, Hanna-Mari Pallari, Mark Henkelman, John Georgiou, Gang Xie, Susan E. Quaggin, Paul S. Thorner, John E. Eriksson, Andras Nagy
Journal of Neuroscience 10 August 2011, 31 (32) 11547-11552; DOI: 10.1523/JNEUROSCI.4396-10.2011
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  • Published on: (30 November 2018)
    RE: About the Nestin KO phenotype

    Greetings.
    I noticed an article published in the Stem Cells 1-year before this one, which also generated a Nestin-/- mouse line and reported a contradictory phenotype:
    Nestin Is Required for the Proper Self‐Renewal of Neural Stem Cells.
    https://doi.org/10.1002/stem.541

    I understand the detailed targeting sites of these two works were not the same.
    But I got confused about the role of Nestin during embryonic CNS development.
    Could you please explain a little bit?

    Thank you very much!

    Competing Interests: None declared.