Figure 1. The majority of RGCs in the rd1 mouse retina exhibit rhythmic spiking. a–d, Spike train properties of RGCs recorded in a 1 mm2 portion of an rd1 retina. a, Spiking activity from 20 selected RGCs. Each tick represent the occurrence of one action potential. The three RGC spike trains in the top row are further evaluated. b, Autocorrelation functions of the three selected rd1 RGCs reveal rhythmic activity with an average interval of ∼150 ms. The peak at zero time lag is omitted. c, The spike train CCs between three selected RGCs reveal strong oscillations. For two cell pairs, the activity is phase-shifted. One RGC pair fires in synchrony revealed by the central peak at zero time lag. Bin size, 4 ms. d, The same CCs as shown in c, computed at higher resolution (bin size, 0.4 ms). A double peak in one CC at zero time lag indicates electrical coupling between the two RGCs. e–h, RGC spike train properties in wt retinas. e, Raster plot of spontaneous activity. f, Autocorrelation function of three selected RGCs. g, Spike train cross-correlations between the three selected RGCs shown in f. Synchronous activity is detected in one cell pair. Bin size, 4 ms. h, The same CCs shown in g, computed at higher resolution, reveal a double peak in one CC around origin, similar to the result in the rd1 retina (d). Bin size, 0.4 ms.