Age in years (range) | 44 (28–55) | 38 (24–56) | ns* |
Sex (number of women) | 7 | 6 | ns* |
MS type | | | |
Relapsing remitting | 12 | n/a | |
Secondary progressive | 1 | n/a | |
Primary progressive | 2 | n/a | |
Median EDSS score (range) | 3 (1–6.5) | n/a | |
Disease duration in years (range) | 8 (1–26) | n/a | |
CC cross-sectional area (mm2) | 575 | 654 | 0.017 |
GM proportion of tVOI | 0.28 | 0.26 | ns |
tNAA/tCr (NAA + NAAG:Cr + PCr ratio) | 1.47 | 1.84 | <0.001 |
Fractional anisotropy | | | |
NAA | 0.53 | 0.58 | ns |
Water | 0.43 | 0.49 | 0.016 |
Mean diffusivity (μm2/ms) | | | |
NAA | 0.15 | 0.18 | ns |
Water | 1.48 | 1.22 | <0.001 |
Parallel diffusivity (λ‖) (μm2/ms) | | | |
NAA | 0.25 | 0.31 | 0.030 |
Water | 2.13 | 1.86 | <0.001 |
Perpendicular diffusivity (λ⊥) (μm2/ms) | | | |
NAA | 0.11 | 0.11 | ns |
Water | 1.15 | 0.90 | <0.001 |