Article Information
- Received June 17, 2011
- Revision received May 10, 2012
- Accepted May 16, 2012
- First published June 27, 2012.
- Version of record published June 27, 2012.
Author Information
- Lydia Danglot1,2,
- Thomas Freret3,
- Nicolas Le Roux4,5,
- Nicolas Narboux Nême4,5,
- Andrea Burgo1,2,
- Vincent Hyenne6,7,
- Anne Roumier4,5,
- Vincent Contremoulins1,8,
- François Dauphin3,
- Jean-Charles Bizot9,
- Guilan Vodjdani10,11,
- Patricia Gaspar4,5,
- Michel Boulouard3,
- Jean-Christophe Poncer4,5,
- Thierry Galli1,2, and
- Marie-Christine Simmler1,2
- 1Centre national de la recherche scientifique (CNRS) UMR7592, Université Paris Diderot, Sorbonne Paris Cité, Institut Jacques Monod, 75205 Paris, France,
- 2Institut National de la Santé et de la Recherche Médicale (INSERM) ERL U950, 75205 Paris, France,
- 3Université Caen Basse-Normandie, EA4259, 14032 Caen, France,
- 4INSERM UMR839, Institut du Fer à Moulin, 75005 Paris, France,
- 5 Université Pierre et Marie Curie, Sorbonne University, Paris, France,
- 6CNRS UMR7104, Université de Strasbourg, Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch, France,
- 7INSERM U964, IGBMC, 67404 Illkirch, France,
- 8ImagoSeine, Institut Jacques Monod, 75205 Paris, France,
- 9Key-Obs SA, Parc Technologique, 45100 Orléans, France,
- 10CNRS UMR7225 Université Pierre et Marie Curie, Sorbonne University, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), GH Pitié-Salpetrière, 75013 Paris, France, and
- 11INSERM UMRS975, Université Pierre et Marie Curie, Sorbonne University, CRICM, GH Pitié-Salpétrière, 75013 Paris, France
Author contributions
Author contributions: L.D., P.G., and M.-C.S. designed research; L.D., T.F., N.L.R., N.N.-N., A.B., V.H., A.R., G.V., M.B., J.C.P., and M.-C.S. performed research; L.D., V.C., F.D., and M.-C.S. contributed unpublished reagents/analytic tools; L.D., T.F., J.-C.B., M.B., J.C.P., and M.-C.S. analyzed data; L.D., P.G., J.C.P., T.G., and M.-C.S. wrote the paper.
Disclosures
- Received June 17, 2011.
- Revision received May 10, 2012.
- Accepted May 16, 2012.
This work was supported by the Fédération de la Recherche sur le Cerveau (M.C.S.), the Association Française contre les Myopathies, the Marie de Paris Medical Research and Health Program, the Fondation pour la Recherche Médicale, and the Ecole des Neurosciences de Paris (T.G.). We thank Dr Günther Schütz (Cancer Research Center, Heidelberg, Germany) for the CamKIIαcre transgenic mice and Dr Stephan Krauss (Institute for Microbiology, Oslo, Norway) for the D6cre transgenic mice; Drs Martin Holzenberger (INSERM U893, Paris, France) and Alessandra Pierani (IJM, Paris, France) for providing adult CamKIIcre and D6cre mice, respectively; Ondrej Machon (Institute of Molecular Genetics, Prague, Czech Republic) for sharing information on the D6cre line; Marie-José Lecomte for Lentivirus-cre supernatant (CRICM, Paris, France); Gérald Née (Université de Caen Basse Normandie, France), Sabrina David, and Alexandre Herpin (Key-Obs SA, Orléans, Paris) for great technical help; Véronique Agin, Pauline Obiang, and Denis Vivien for providing the fear conditioning system (Université de Caen Basse-Normandie, France); Xavier Baudin, Lamia Baba-Aissa, and Aude Jobart-Malfait (ImagoSeine, IJM, Paris, France) for constant support in imaging and software manipulations; Dr Marika Nosten-Bertrand (INSERM U513, Paris, France) for enthusiastic help and discussions, and Kathleen Zylbersztejn and Thierry Galli's group for support and criticisms. We are especially grateful to Professor Christine Petit (Institut Pasteur, INSERM UMRS587, Collège de France, Paris, France) for critical reading of the manuscript.
The authors declare no competing financial interests.
- Correspondence should be addressed to Marie-Christine Simmler, Institut Jacques Monod, 15 rue Hélène Brion, 75205 Paris, France. simmler.marie-christine{at}ijm.univ-paris-diderot.fr
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