Article Information
- Received October 26, 2011
- Revision received May 21, 2012
- Accepted May 23, 2012
- First published July 18, 2012.
- Version of record published July 18, 2012.
Author Information
- Ernest C. Y. Ho1,3,
- Michael Strüber4,5,6,7,
- Marlene Bartos4,5,
- Liang Zhang1,2, and
- Frances K. Skinner1,2,3
- 1Toronto Western Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada,
- 2Department of Medicine (Neurology), and
- 3Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada,
- 4Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom,
- 5Physiological Institute I,
- 6Spemann Graduate School of Biology and Medicine, and
- 7Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany
Author contributions
Author contributions: E.C.Y.H. and F.K.S. designed research; E.C.Y.H., M.S., and L.Z. performed research; E.C.Y.H. and M.S. analyzed data; E.C.Y.H., M.S., M.B., L.Z., and F.K.S. wrote the paper.
Disclosures
- Received October 26, 2011.
- Revision received May 21, 2012.
- Accepted May 23, 2012.
This work was supported by a Natural Sciences and Engineering Research Council of Canada Discovery Grant (L.Z., F.K.S.) and a PGS-D award (E.C.Y.H.); Queen Elizabeth II Graduate Scholarship in Science and Technology of Ontario (E.C.Y.H.); University of Toronto Open Fellowships (E.C.Y.H.); Lichtenberg Award, VW-Foundation (M.B.); BIOSS Centre for Biological Signalling Studies (M.B.); and Excellence Initiative of the German Federal and State Governments (GSC-4, Spemann Graduate School) (M.S.). Computations were performed on the GPC supercomputer at the SciNet HPC Consortium. SciNet is funded by the Canada Foundation for Innovation under the auspices of Compute Canada; the Government of Ontario; Ontario Research Fund Research Excellence; and the University of Toronto. We thank Dr. Nathan Insel for critical reading of the manuscript and the reviewers for constructive comments.
- Correspondence should be addressed to Frances K. Skinner, Toronto Western Research Institute, University Health Network, MP13-317, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada. frances.skinner{at}utoronto.ca
Online Impact