Article Information
- Received February 7, 2012
- Revision received May 25, 2012
- Accepted June 1, 2012
- First published July 25, 2012.
- Version of record published July 25, 2012.
Author Information
- Megan E. Larson1,2,3,
- Mathew A. Sherman1,2,3,
- Susan Greimel1,
- Michael Kuskowski4,
- Julie A. Schneider5,
- David A. Bennett5, and
- Sylvain E. Lesné1,2,3
- 1Department of Neuroscience,
- 2N. Bud Grossman Center for Memory Research and Care, and
- 3Institute for Translational Neuroscience, University of Minnesota, Minneapolis, Minnesota 55414,
- 4Geriatric Research Education Clinical Center, VA Medical Center, Minneapolis, Minnesota 55417, and
- 5Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612
Author contributions
Author contributions: S.E.L. designed research; M.E.L., M.A.S., S.G., and S.E.L. performed research; J.A.S. and D.A.B. contributed unpublished reagents/analytic tools; M.E.L., M.A.S., S.G., M.K., D.A.B., and S.E.L. analyzed data; M.E.L. and S.E.L. wrote the paper.
Disclosures
- Received February 7, 2012.
- Revision received May 25, 2012.
- Accepted June 1, 2012.
The authors declare no competing financial interests.
This work was supported in part by NIH Grants P30AG10161 and R01AG15819 (D.A.B.) and startup funds from the Minnesota Medical Foundation and NIH Grant R00AG031293 (S.E.L.). We thank Karen H. Ashe for critical discussions and Tg2576 protein extracts; Michael K. Lee for critical discussions and brain tissues from transgenic αSyn-A53T line G2.3; Lennart Mucke for J20 brain tissues; Robert Edwards and Dennis Selkoe for critical discussions; Harry Orr and Dennis Selkoe for comments on this manuscript; and Kenji Takamura, Hoa Nguyen, and Cassondra Kowalski for technical help. We thank the participants in the Religious Orders Study.
- Correspondence should be addressed to Dr. Sylvain E. Lesné, Institute for Translational Neuroscience Scholar, Department of Neuroscience, Wallin Medical Biosciences Building, 5-180, University of Minnesota, 2101 Sixth Street SE, CDC 2641, Minneapolis, MN 55414. lesne002{at}umn.edu
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