Figure 7. Modifications of AMPAR subunit complex after 6-OHDA lesion and pharmacological treatments. A, Top of the graph shows example of an individual experiment obtained in control condition to calculate the IR of AMPAR (scale bars, 50 ms and 100 pA). In the bottom, the bar graph shows the IR in the different groups, calculated as the ratio of the AMPAR-mediated EPSCs recorded at −70 mV and +40 mV (n = 7 6-OHDA vs n = 8 CTRL, **p < 0.01; n = 11 l-DOPA vs CTRL, ***p < 0.001; n = 7 pramipexole 1 mg/kg vs CTRL, **p < 0.01; n = 7 6-OHDA vs pramipexole 0.3 mg/kg, ## p < 0.01; l-DOPA vs pramipexole 0.3 mg/kg, ###p < 0.001; pramipexole 1 mg/kg vs pramipexole 0.3 mg/kg, #p < 0.05; one-way ANOVA with Bonferroni comparison). B, IR values obtained from pramipexole-treated and l-DOPA-treated rats were correlated with AIM score. The linear regression revealed a significant correlation between these two variables among the pramipexole-treated group (n = 11 l-DOPA, Pearson's r = 0.0238, p > 0.05; n = 13 pramipexole, Pearson's r = 0.7126, p < 0.01). C, Decay time constants of AMPAR, calculated by fitting with a single exponential, are summarized in the bar graph.