Figure 8. BDNF suppressed GABA receptor transmission in the IL-mPFC pyramidal neurons of wild-type mice but not BDNFMet/Met mice. A, Average mIPSC frequency in the layer II/III pyramidal neurons of untreated wild-type (n = 14), untreated BDNFMet/Met (n = 15), BDNF-treated wild-type (n = 15), and BDNF-treated BDNFMet/Met brain slices (n = 14). BDNF suppressed mIPSC frequency in wild-type mice (p < 0.001) but not in BDNFMet/Met mice (p > 0.05). B, Average mIPSC amplitude in the layer II/III pyramidal neurons of untreated wild-type (n = 14), untreated BDNFMet/Met (n = 15), BDNF-treated wild-type (n = 15), and BDNF-treated BDNFMet/Met brain slices (n = 14). BDNF failed to modify mIPSC amplitude in wild-type and BDNFMet/Met mice (p > 0.05). C, Average mIPSC frequency in the layer V pyramidal neurons of untreated wild-type (n = 13), untreated BDNFMet/Met (n = 17), BDNF-treated wild-type (n = 15), and BDNF-treated BDNFMet/Met brain slices (n = 18). BDNF suppressed mIPSC frequency in wild-type mice (p < 0.05) but not in BDNFMet/Met mice (p > 0.05). D, Average mIPSC amplitude in the layer V pyramidal neurons of untreated wild-type (n = 13), untreated BDNFMet/Met (n = 17), BDNF-treated wild-type (n = 15) and BDNF-treated BDNFMet/Met brain slices (n = 18). BDNF suppressed mIPSC amplitude in wild-type neurons (p < 0.05) but not in BDNFMet/Met neurons (p > 0.05). Asterisks denote statistical significance.