Figure 3. A, Head-twitch behavioral response is increased in adult mice born to stressed mothers during pregnancy. Mice were injected with DOI (0.5, 1.0, or 2.0 mg/kg), or vehicle (n = 6–10). ***p < 0.001, Bonferroni's post hoc test of two-way ANOVA. B–D, Decreased effect of LY379268 on the MK801-stimulated locomotor activity in the offspring of stressed mothers during pregnancy (C, D, white) compared with controls (B, D, black). The panels depict the time course of MK801-induced locomotion in 5 min blocks (B, C). Mice were administered LY379268 (5 mg/kg) or vehicle, followed by MK801 or vehicle. Time of injections is indicated by arrows. D, Data summary of the total MK801-induced locomotor response as a summation of horizontal activity from t = 20 to t = 120. Mice were administered LY379268 (3.0, 5.0, or 8.0 mg/kg) or vehicle, followed by MK801 or vehicle (n = 9–18 per group). *p < 0.05, Bonferroni's post hoc test of two-way ANOVA. All data are presented as mean ± SEM.