Article Information
- Received June 13, 2013
- Revision received October 3, 2013
- Accepted October 22, 2013
- First published December 4, 2013.
- Version of record published December 4, 2013.
Author Information
- Jeremy H. Herskowitz1,2,
- Yangbo Feng5,
- Alexa L. Mattheyses3,
- Chadwick M. Hales1,2,
- Lenora A. Higginbotham1,2,
- Duc M. Duong4,
- Thomas J. Montine6,
- Juan C. Troncoso7,
- Madhav Thambisetty8,
- Nicholas T. Seyfried1,4,
- Allan I. Levey1,2, and
- James J. Lah1,2
- 1Center for Neurodegenerative Disease, and
- 2Departments of Neurology,
- 3Cell Biology, and
- 4Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322,
- 5Medicinal Chemistry, Translational Research Institute, The Scripps Research Institute, Jupiter, Florida 33458,
- 6Department of Pathology, University of Washington, Seattle, Washington 98104,
- 7Departments of Pathology and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and
- 8Unit of Clinical and Translational Neuroscience and Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224
Author contributions
Author contributions: J.H.H., N.T.S., A.I.L., and J.J.L. designed research; J.H.H., A.L.M., C.M.H., L.A.H., and D.M.D. performed research; J.H.H., Y.F., T.J.M., J.C.T., and M.T. contributed unpublished reagents/analytic tools; J.H.H., Y.F., A.L.M., C.M.H., D.M.D., N.T.S., A.I.L., and J.J.L. analyzed data; J.H.H., A.I.L., and J.J.L. wrote the paper.
Disclosures
- Received June 13, 2013.
- Revision received October 3, 2013.
- Accepted October 22, 2013.
This work was supported by the National Institutes of Health through National Institute on Aging (NIA) Grant 5K99AG043552–02 to J.H.H., National Institute of Neurological Disorders and Stroke (NINDS) Grant P30NS055077, and NIA Grants AG025688, P01AG1449, and AG05136. This work was supported in part by the NIA Intramural Research Program of the National Institutes of Health. J.C.T. was supported by grants from the Johns Hopkins University Alzheimer's Disease Research Center (NIAAG05146) and the Alzheimer's Association (IIRG-09-134090). N.T.S. is supported by Alzheimer's Association Grant NIRG-12-242297. We thank the donors of ADR, a program of the BrightFocus Foundation, for support of this research. This research project was supported in part by the Emory University Integrated Cellular Imaging Microscopy Core of the Emory Neuroscience NINDS Core Facilities grant. We thank Dr. Ranjita Betarbet and Craig Heilman for technical assistance.
The authors declare no competing financial interests.
- Correspondence should be addressed to Dr. James J. Lah, Center for Neurodegenerative Disease, 615 Michael Street, Suite 505, Atlanta, GA 30322. jlah{at}emory.edu
Online Impact