Article Information
- Received June 17, 2013
- Revision received October 23, 2013
- Accepted November 2, 2013
- First published December 11, 2013.
- Version of record published December 11, 2013.
Author Information
- Xinyi Li1,
- Xin Zhang2,4,
- Ali Reza A. Ladiwala5,
- Deguo Du6,
- Jay K. Yadav7,
- Peter M. Tessier5,
- Peter E. Wright3,4,
- Jeffery W. Kelly1,2,4, and
- Joel N. Buxbaum1
- 1Departments of Molecular and Experimental Medicine,
- 2Chemistry, and
- 3Molecular Biology and
- 4The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037,
- 5Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180,
- 6Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431, and
- 7Max Planck Research Unit for Enzymology of Protein Folding and Martin Luther University, D-06120 Halle, Germany
Author contributions
Author contributions: X.L., P.M.T., P.E.W., and J.N.B. designed research; X.L., X.Z., A.R.A.L., D.D., and J.K.Y. performed research; J.W.K. contributed unpublished reagents/analytic tools; X.L., X.Z., A.R.A.L., D.D., J.K.Y., P.M.T., P.E.W., J.W.K., and J.N.B. analyzed data; X.L., X.Z., J.W.K., and J.N.B. wrote the paper.
Disclosures
- Received June 17, 2013.
- Revision received October 23, 2013.
- Accepted November 2, 2013.
The authors declare no competing financial interests.
The work was supported by National Institutes of Health Grant AG R01 030027 (J.N.B.) and the W.M. Keck Foundation (J.N.B., X.L.). X.Z. is a Howard Hughes Medical Institute Fellow of the Helen Hay Whitney Foundation. We thank Michael Saure for synthesizing Aβ peptide, Dr. Jean-Philippe Julien for his assistance with the ITC analysis and discussion, Prof. Jane Dyson for suggestions regarding experimental design, Prof. Hun Lim and Drs. Lei Zhao, Goran Pljevaljcic, Amber Murray, Jiyong Lee, and Kanchan Garai for complementary experiments (not included), Prof. Ian Wilson for access to the MicroCal instrument, and Gerard Koon for technical assistance with the NMR experiments. We also thank Drs. Evan Powers, John Hulleman, Francesca Cattaneo, and Natalia Reixach for insightful discussions. Prof. Fabrizio Chiti allowed us access to his unpublished data.
- Correspondence should be addressed to either Xinyi Li or Joel N. Buxbaum, Department of Molecular and Experimental Medicine, Room 230, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037. Xinyili{at}scripps.edu, Jbux{at}scripps.edu
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