a | 100 nM KA control series 1 | 1.24 × 10−09 ± 1.31 × 10−10 | 19 | | | | |
b | 2 nM Aβ, 180 min | 8.26 × 10−10 ± 1.66 × 10−10 | 8 | 106 | 19 | 8 | 0.119 |
c | 50 nM Aβ, 180 min | 2.54 × 10−10 ± 8.28 × 10−11 | 8 | 143 | 19 | 8 | <0.0001 |
d | 500 nM Aβ, 180 min | 1.79 × 10−10 ± 6.16 × 10−11 | 8 | 146 | 19 | 9 | <0.0001 |
e | 1 μM Aβ, 180 min | 1.95 × 10−11 ± 9.55 × 10−12 | 8 | 114 | 19 | 6 | <0.0001 |
f | 1 μM EDTA solution, 180 min | 1.99 × 10−09 ± 1.01 × 10−09 | 7 | 69 | 19 | 7 | 0.91 |
g | 1 μM Aβ, 15 min | 1.38 × 10−10 ± 5.11 × 10−11 | 9 | 168 | 19 | 9 | <0.0001 |
h | 1 μM Aβ, 30 min | 1.38 × 10−10 ± 5.19 × 10−11 | 10 | 185 | 19 | 10 | <0.0001 |
i | 1 μM Aβ, 60 min | 5.53 × 10−11 ± 1.56 × 10−11 | 9 | 170.5 | 19 | 9 | <0.0001 |
j | 1 μM Aβ, 120 min | 2.21 × 10−11 ± 6.05 × 10−12 | 15 | 285 | 19 | 15 | <0.0001 |
k | 50 nM Aβ, 15 min | 6.86 × 10−10 ± 1.68 × 10−10 | 8 | 119.5 | 19 | 8 | 0.019 |
l | 50 nM Aβ, 15 min + 180 min washout | 8.20 × 10−10 ± 2.32 × 10−10 | 7 | 25 | 7 | 7 | 1 |
m | 100 nM KA control series 2 | 5.58 × 10−09 ± 3.98 × 10−10 | 16 | | | | |
n | 50 nM Monomeric Aβ, 15 min | 3.71 × 10−09 ± 5.59 × 10−10 | 14 | 167 | 16 | 14 | 0.022 |
o | 50 nM Mixed Aβ, 15 min | 1.97 ×10−09 ± 2.98 × 10−10 | 12 | 130 | 14 | 12 | 0.017 |
p | 50 nM Fibrillar Aβ, 15 min | 1.08 × 10−09 ± 1.11 × 10−10 | 12 | 107 | 12 | 12 | 0.04 |
q | 50 nM Spider silk fibrils, 15 min | 6.27 × 10−09 ± 2.03 × 10−10 | 6 | 56 | 16 | 6 | 0.59 |
r | 50 nM Spider silk fibrils, 180 min | 5.19 × 10−09 ± 1.85 × 10−10 | 5 | 46 | 16 | 5 | 0.66 |
s | 250 nM Dec-DETA + 50 nM monomeric Aβ | 7.68 × 10−09 ± 6.22 × 10−10 | 8 | 85 | 16 | 8 | 0.214 |
t | 250 nM Dec-DETA + 50 nM mixed Aβ | 4.94 × 10−09 ± 4.08 × 10−10 | 14 | 134 | 16 | 14 | 0.377 |
u | 250 nM Dec-DETA + 50 nM fibrillar Aβ | 3.55 ×10−09 ± 3.42 × 10−10 | 8 | 109 | 16 | 8 | 0.0045 |
v | 250 nM Dec-DETA | 5.55 × 10−09 ± 5.23 × 10−10 | 8 | 64.5 | 16 | 8 | 0.976 |
w | 1 μM BRICHOS + 50 nM monomeric Aβ | 5.06 × 10−09 ± 3.23 × 10−1 | 15 | 144.5 | 16 | 15 | 0.337 |
x | 1 μM BRICHOS + 50 nM mixed Aβ | 5.43 × 10−09 ± 3.49 × 10−10 | 8 | 71 | 16 | 8 | 0.697 |
y | 1 μM BRICHOS + 50 nM fibrillar Aβ | 2.72 × 10−09 ± 3.54 × 10−10 | 8 | 121 | 16 | 8 | 0.00012 |
z | 1 μM BRICHOS | 5.22 × 10−09 ± 1.07 × 10−10 | 8 | 77 | 16 | 8 | 0.452 |