Cover legend: These synapses in mouse somatosensory cortex were stained with ethanolic phosphotungstic acid for electron microscopy. Synapses were identified using a machine-learning algorithm to enable a high-throughput analysis of experience-dependent changes in synapse properties across the cortical column. For this image, candidate synapses were selected from electron micrographs and aligned, then pseudocolored for contrast. Image credit: Saket Navlakha and Alison Barth. Image credit: Saket Navlakha and Alison L. Barth. For more information, see the article by Chandrasekaran et al. (pages 16450–16462).