Article Information
- Received May 1, 2015
- Revision received March 30, 2016
- Accepted April 3, 2016
- First published May 18, 2016.
- Version of record published May 18, 2016.
Author Information
- Kelly E. Glajch1,*,
- Daniel A. Kelver1,*,
- Daniel J. Hegeman1,*,
- Qiaoling Cui1,
- Harry S. Xenias1,
- Elizabeth C. Augustine1,
- Vivian M. Hernández1,
- Neha Verma1,
- Tina Y. Huang1,
- Minmin Luo2,3,
- Nicholas J. Justice4, and
- C. Savio Chan1
- 1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611,
- 2National Institute of Biological Sciences, Beijing 102206, China,
- 3School of Life Sciences, Tsinghua University, Beijing 100084, China, and
- 4Institute of Molecular Medicine, University of Texas, Houston, Texas 77030
Author contributions
Author contributions: K.E.G., D.A.K., D.J.H., Q.C., H.S.X., E.C.A., V.M.H., and C.S.C. designed research; K.E.G., D.A.K., D.J.H., Q.C., H.S.X., E.C.A., V.M.H., T.Y.H., and C.S.C. performed research; M.L. and N.J.J. contributed unpublished reagents/analytic tools; K.E.G., D.A.K., D.J.H., Q.C., H.S.X., E.C.A., V.M.H., N.V., and C.S.C. analyzed data; K.E.G., D.J.H., and C.S.C. wrote the paper.
↵*K.E.G., D.A.K., and D.J.H. are co-first authors.
Disclosures
- Received May 1, 2015.
- Revision received March 30, 2016.
- Accepted April 3, 2016.
This work was supported by grants from the Parkinson's Disease Foundation and National Institutes of Health (NIH) Grant NS 041234 (to K.E.G.); NIH Grant NS 041234 (to H.S.X.); the China Ministry of Science and Technology Science Fund for Creative Research Group of China Grants 2012CB837701 and 2012YQ03026005, and National Natural Science Foundation of China Grant 91432114 (to M.L.); NIH Grant AG 036738 (to N.J.J.); and Northwestern Memorial Foundation Parkinson's Disease and Movement Disorders Advisory Council Grant, American Parkinson Disease Association, and NIH Grants NS 069777, NS 069777-S1, and NS 047085 (to C.S.C.). We thank Ellie Hong, Bonnie Erjavec, Jason Barraza, Yu Chen, Michael Fiske, and Thomas Madathany for their technical assistance; and members of the Chan laboratory for discussions. We also thank Eileen McIver and Dr. Mark Bevan for sharing their DREADD virus and experience with chemogenetic experiments. Finally, we thank Drs. Vandana Chinwalla and Sanza Kazadi from the Illinois Mathematics and Science Academy for their opportunity for the partnership with the SIR program.
The authors declare no competing financial interests.
- Correspondence should be addressed to C. Savio Chan, Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611. saviochan{at}gmail.com
Online Impact