Article Information
- Received May 15, 2016
- Revision received September 6, 2016
- Accepted September 6, 2016
- First published October 26, 2016.
- Version of record published October 26, 2016.
Author Information
- Shan Lou1,
- Yoav Adam1,
- Eli N. Weinstein1,2,
- Erika Williams3,
- Katherine Williams1,
- Vicente Parot1,
- Nikita Kavokine1,
- Stephen Liberles3,
- Linda Madisen4,
- Hongkui Zeng4, and
- Adam E. Cohen1,2,5
- 1Department of Chemistry and Chemical Biology and
- 2Department of Physics, Harvard University, Cambridge, Massachusetts 02138,
- 3Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115,
- 4Allen Institute for Brain Science, Seattle, Washington 98107, and
- 5Howard Hughes Medical Institute, Chevy Chase, Maryland 20815
Author contributions
Author contributions: S. Lou, Y.A., E.W., S. Liberles, L.M., H.Z., and A.E.C. designed research; S. Lou, Y.A., E.W., K.W., N.K., and L.M. performed research; E.W. and S. Liberles contributed unpublished reagents/analytic tools; S. Lou, E.N.W., V.P., L.M., H.Z., and A.E.C. analyzed data; S. Lou, E.N.W., and A.E.C. wrote the paper.
Disclosures
- Received May 15, 2016.
- Revision received September 6, 2016.
- Accepted September 6, 2016.
This work was supported by the Howard Hughes Medical Institute, the Allen Institute for Brain Science, and GlaxoSmithKline (Bioelectronic Medicines Initiative Grant). A.E.C. is supported by National Institutes of Health (NIH) Grant 1-R01-EB012498. Y.A. is supported by a long-term fellowship of the Human Frontier Science Program. E.W. is supported by NIH Grants F30CA177170 and T32GM007753. S. Liberles is supported by NIH Grant DK103703. We thank Vaibhav Joshi and Melinda Lee for technical assistance. We thank Qiufu Ma, Xinzhong Dong, Rohini Kuner, Venkatesh Murthy, and Paola Arlotta for scientific discussions and for sharing Cre driver mouse lines; Corey Smith, Stephen Lewis, and Paulina Getsy for training and assistance; the Harvard University Genome Modification Facility for technical support in generating transgenic mice; and the Harvard Center for Brain Sciences for providing confocal imaging facilities.
A.E.C. is a founder of Q-State Biosciences. The remaining authors declare no competing financial interests.
- Correspondence should be addressed to Adam E. Cohen, Department of Chemistry and Chemical Biology, Harvard University, Mallinckrodt 115, 12 Oxford Street, Cambridge, MA 02138. cohen{at}chemistry.harvard.edu
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