Figure 3. Effect of Slco2a1 deficiency on PGE2 disposition in the brain. A, Time course of Ccsf in Slco2a1+/+ (open, n = 3–4) and Slco2a1−/− (filled, n = 3–4) mice treated with LPS (100 μg/kg, i.p.). B, Time course of Cisf in Slco2a1+/+ (open, n = 7) and Slco2a1−/− (filled, n = 6) mice treated with LPS (100 μg/kg, i.p.). C, D, Chyp (C) and Ccor (D) in Slco2a1+/+ (open, n = 3–6) and Slco2a1−/− (filled, n = 3–6) mice treated with LPS (100 μg/kg or 20 mg/kg, i.p.). Tissue concentration was normalized by wet weight of tissue. E, Cp in Slco2a1+/+ (open, n = 4) and Slco2a1−/− (filled, n = 4) mice at 1 h after LPS treatment (100 μg/kg, i.p.). Each point or bar represents the mean ± SEM. The asterisk indicates statistically significant differences (p < 0.05) by Student's t test.