Article Information
- Received December 13, 2017
- Revision received August 31, 2018
- Accepted September 19, 2018
- First published September 28, 2018.
- Version of record published November 7, 2018.
Author Information
- Remya R. Nair1,
- Henna Koivisto4,
- Kimmo Jokivarsi4,
- Ilkka J. Miinalainen2,
- Kaija J. Autio1,
- Aki Manninen1,3,
- Pekka Poutiainen5,
- Heikki Tanila4,
- J. Kalervo Hiltunen1, and
- Alexander J. Kastaniotis1
- 1Faculty of Biochemistry and Molecular Medicine,
- 2Electron Microscopy Core Facility,
- 3Virus Core Facility, Biocenter Oulu, University of Oulu, FI-90014 Oulu, Finland,
- 4A.I. Virtanen Institute, University of Eastern Finland, FI-70211 Kuopio, Finland, and
- 5Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, FI-70029 Kuopio, Finland
Author contributions
Author contributions: R.R.N., A.M., H.T., J.K.H., and A.J.K. designed research; R.R.N., H.K., K.J., I.M., K.J.A., P.P., H.T., and J.K.H. performed research; R.R.N., H.K., K.J., I.M., K.J.A., A.M., P.P., H.T., J.K.H., and A.J.K. analyzed data; R.R.N., H.K., K.J., I.M., K.J.A., A.M., H.T., J.K.H., and A.J.K. wrote the paper; A.M. contributed unpublished reagents/analytic tools.
Disclosures
- Received December 13, 2017.
- Revision received August 31, 2018.
- Accepted September 19, 2018.
This work was supported by the Academy of Finland, the Sigrid Jusélius Foundation, the Finnish Cultural Foundation, the European Regional Development Fund project A71429, and Biocenter Finland. We thank Raija Soininen for continuous support at various stages of this project and critical review of this manuscript; The Biocenter Oulu Transgenic Core facility, the Biocenter Oulu EM laboratory, and the Biocenter Oulu Virus Core laboratory, which are all part of Biocenter Finland, for support in generating mice, EM analysis, and lentivirus production, respectively; Dr. Pekka Poutiainen (Department of Clinical Physiology and Medicine, Kuopio University Hospital, Finland) for his contribution in obtaining the PET scans; Juha M. Kerätär for providing the Mecrtm1c strain for the project; Leena Ollitervo, Anna Sofia Kuusisto, Miriam Martens, Jessica Müller, and Belen Sintes Garcia for technical help with histology samples; Anna von Schaewen and Ujjwal Suwal for work on the quantitation of fluorescence image data; and Randy Woltjer (Oregon Health and Science University) for reviewing H&E-stained cerebellar sections. The project was funded by the Academy of Finland, the Sigrid Jusélius Foundation, Finnish Cultural Foundation, the European regional Development Fund project A71429, and Biocenter Finland.
The authors declare no competing financial interests.
- Correspondence should be addressed to Alexander J. Kastaniotis, Faculty of Biochemistry and Molecular Medicine, University of Oulu, P.O. Box 5400, FI-90014 Oulu, Finland. alexander.kastaniotis{at}oulu.fi
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