Article Information
- Received November 7, 2016
- Revision received February 27, 2017
- Accepted March 2, 2017
- First published March 8, 2017.
- Version of record published April 12, 2017.
Author Information
- Chia-Chen Liu1,
- Jin Hu1,3,
- Na Zhao1,
- Jian Wang1,
- Na Wang1,3,
- John R. Cirrito2,
- Takahisa Kanekiyo1,
- David M. Holtzman2, and
- Guojun Bu1,3
- 1Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224,
- 2Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, and
- 3Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, 361102 China
Author contributions
Author contributions: C.-C.L., J.H., N.Z., J.R.C., T.K., D.M.H., and G.B. designed research; C.-C.L., J.H., N.Z., J.W., and N.W. performed research; J.R.C. contributed unpublished reagents/analytic tools; C.-C.L., J.H., N.Z., J.W., and N.W. analyzed data; C.-C.L. and G.B. wrote the paper.
Disclosures
- Received November 7, 2016.
- Revision received February 27, 2017.
- Accepted March 2, 2017.
This work was supported by National Institutes of Health Grants R01AG027924, R01AG046205, RF1AG051504, R01AG035355, and P50AG016574 to G.B., P01NS074969 to G.B., J.R.C., and D.M.H., Cure Alzheimer's Foundation Grant to G.B., American Heart Association Grant 15SDG22460003 to T.K., and American Heart Association Fellowship to C.-C.L. We thank Dr. Mingjie Li and Nada Husic (Washington University Viral Vectors Core) for producing the lentiviruses; Dr. Pritam Das for providing the γ-secretase inhibitor LY411575; and Dr. Dennis Dickson, Monica Castanedes Casey, Linda Rousseau, and Virginia Phillips for histology and immunohistochemical analyses.
The authors declare no competing financial interests.
- Correspondence should be addressed to either Dr. Guojun Bu or Dr. Chia-Chen Liu, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224. bu.guojun{at}mayo.edu or liu.chiachen{at}mayo.edu
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