Article Information
- Received May 18, 2017
- Revision received November 3, 2017
- Accepted November 26, 2017
- First published December 11, 2017.
- Version of record published January 24, 2018.
Author Information
- Emilia Servián-Morilla1,2,
- Estefanía Robles-Lanuza1,2,*,
- Ana C. Sánchez-Hidalgo1,2,*,
- Rafael J. Camacho-Garcia1,2,
- Juan A. Paez-Gomez1,2,
- Fabiola Mavillard1,2,3,
- Carlos A. Saura3,4,
- Amalia Martinez-Mir1, and
- Francisco G. Scholl1,2
- 1Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Sevilla, 41013 Sevilla, Spain,
- 2Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain,
- 3Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, 28031 Madrid, Spain, and
- 4Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain
Author contributions
Author contributions: E.S.-M., E.R.-L., and F.G.S. designed research; E.S.-M., E.R.-L., A.C.S.-H., and R.J.C.-G. performed research; F.M. and C.A.S. contributed unpublished reagents/analytic tools; E.S.-M., E.R.-L., A.C.S.-H., J.A.P.-G., A.M.-M., and F.G.S. analyzed data; A.M.-M. and F.G.S. wrote the paper.
↵*E.R.-L. and A.C.S.-H. contributed equally to this work
Disclosures
- Received May 18, 2017.
- Revision received November 3, 2017.
- Accepted November 26, 2017.
This work was funded by Junta de Andalucía (Grant P11-CVI-7599) and Ministerio de Economía y Competitividad (MINECO) (Grant BFU2015-71464-R) and cofunded by Fondo Europeo de Desarrollo Regional (FEDER) funds. E.S.-M. was a recipient of a fellowship from Junta de Andalucía. E.R.-L. is a fellow from V Plan Propio de Investigación (Universidad de Sevilla). A.C.S.-H. received a fellowship from Junta de Andalucía. Part of the study was performed at Centro de Investigación Tecnológica e Innovación (CITIUS) (Universidad de Sevilla). We thank J. Shen for providing fPS1/fPS1 and PS2−/− mice and Cre constructs, D. Selkoe for PS1 vectors, L. Lagnado for the gift of the SypHy construct, F.J. Morón from the IBiS Genomics Service for technical support and Rafael Fernández-Chacón for discussion and critical reading of the manuscript.
The authors declare no competing financial interests.
- Correspondence should be addressed to Francisco G. Scholl, Instituto de Biomedicina de Sevilla (IBiS), Avda Manuel Siurot s/n, 41013 Sevilla, Spain. fgs{at}us.es
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