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Cover picture: Double-exposure of a rat spinal cord motor neuron indicating accurate regeneration into its original terminal nerve branch. The original neuronal pools projecting to the quadriceps muscle were labeled with the fluorescent dye Dil (red) before lesioning of the parent femoral nerve. Four weeks after nerve repair, neurons that regenerated axons into the terminal motor branch to the quadriceps muscle were labeled with Fluorogold (yellow). Neurons that contain both dyes appear orange when photographed as a double-exposure. The tissue section was counterstained with bisbenzimide (blue) to label the nuclei of all cells. Both motor and sensory afferent neurons to muscle display a strong preference to regenerate into their original terminal nerve branch. Understanding the basis of this specificity in the regeneration process may lead to improved strategies for clinical nerve repair. See the article in this issue by Madison et al. (pp. 5698-5703).
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