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Cover picture: Three perspectives on mouse trisomy 16. (Clockwise from top left) Fluorescence in situ hybridization using a mouse chromosome 16 (MMU16)-specific paint probe identifies an extra copy of MMU16 in fetal hepatocytes from trisomic animals. Trisomy 16 fetuses (right) exhibit craniofacial abnormalities as well as conspicuous edema at embryonic day 16. The brains of trisomy 16 mice (right) are smaller, and growth of the cerebral cortical layers is stunted at midgestation. See the article by Haydar et al. in this issue (pp. 6175-6182).