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Cover picture: Localization of cannabinoid activation of G-proteins in rat brain by in vitro autoradiography of agonist-stimulated [³⁵S]GTPS binding. Shown is the differential activation of G-proteins in rat brain by two cannabinoid receptor agonists, WIN 55212-2, a full agonist (top), and ⁹-THC, a partial agonist (bottom). Autoradiograms reveal the localization of intracellular transducers coupled to cannabinoid receptors, particularly in globus pallidus, entopeduncular nucleus, and substantia nigra. Because ⁹-THC was a partial agonist in this system, its overall activation was much less than that of a full agonist like WIN 55212-2. Nevertheless, chronic treatment of rats with ⁹-THC produced marked desensitization of cannabinoid receptor-coupling to G-proteins. See the article by Sim et al. in this issue (pp. 8057-8066).
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