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Cover picture: Internalization of substance P receptors by spinal cord neurons after an acute noxious thermal stimulus. A confocal image of substance P receptors (yellow), substance P (red) immunoreactivity, and cell nuclei (blue) in lamina I of rat lumbar spinal cord 8 min after a 30 sec thermal (20°C) stimulus. The noxious thermal stimulus induces a release of substance P from the primary afferent neurons that terminate in lamina I, which in turn induces the internalization of substance P receptors that are expressed by the postsynaptic spinal cord neurons. For details, see the article by Allen et al. (pp. 5921-5927).
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