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Cover picture: Immunohistochemical detection of AMPA receptor subunits in the rat neostriatum. Top left, GluR1 subunit immunolabeling of striatal neurons by the peroxidase method at the light microscopic level. The heavily labeled neuron was identified as a GABAergic interneuron. Main picture, Subcellular localization of GluR1 using the preembedding immunogold method. The electron micrograph shows an immunolabeled dendrite that receives input from several boutons forming asymmetrical synapses. Some of the synapses have immunoparticles associated with either the body or the edge of the postsynaptic membrane specialization. Bottom right, Diagram summarizing the distribution of AMPA receptors along the postsynaptic membrane specialization of axospinous synapses. These data were derived from the analysis of the distribution of immunoparticles for GluR1 and GluR2/3 subunits at axospinous synapses labeled by the postembedding immunogold method. AMPA receptors are concentrated at the periphery of the postsynaptic membrane specialization. See the article in this issue by Bernard et al. (pp. 819-833).
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