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Cover picture: Loss of Purkinje neurons in the aged NFHLacZ transgenic mice (top two panels) compared with age-matched control (bottom two panels). The left column is cerebellum-stained with cresyl violet, and the right column is cerebellum-stained with a monoclonal antibody RMdO9, raised against the nonphosphorylated high-molecular-weight neurofilament protein. Note the remarkable loss of Purkinje cells in the 18-month-old NFHLacZ transgenic mouse (top row) versus age-matched nontransgenic littermate (bottom row). See the article by Tu et al. in this issue (pp. 1064-1074).