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Cover picture: Taste bud from the nasoincisor duct
of the rat's palate, showing an optical reconstruction (14 1-µm optical sections) of immunofluorescence labeling for
-gustducin in
several taste cells (green) on a background of a single
optical section through the center of the taste bud, depicting cell
nuclei stained with propidium iodide (red).
-Gustducin is
a taste-specific G-protein that has been implicated in the transduction
of both sweet and bitter stimuli. It is expressed in significantly more cells in taste buds of the rat's posterior tongue and palate, areas
that are very sensitive to bitter and sweet stimuli, respectively, than
in fungiform taste buds on the rat's anterior tongue, which are
relatively insensitive to both classes of stimuli. See the article in
this issue by Boughter et al. (pp. 2852-2858).
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