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Cover picture: Rat hippocampal slice stained with rhodamine 123 reveals mitochondrial potential is altered in proportion to electrical activity on a dynamic basis. Change in mitochondrial potential is revealed by calculation of the pixel-by-pixel SD for fluorescence intensity from a series of six time-lapsed images before (top) and after (bottom) electrical stimulation that induced epileptiform burst activity (STIB). SD is plotted on the z-axis and color-coded to demonstrate the spatial localization and magnitude of the change. Mitochondrial potential changes attributable to endogenous, spontaneous electrical activity are shown in the top set of images as seen by the peak within the entorhinal cortex and dentate gyrus. STIB (red trace in background) produced long-lasting waves of mitochondrial depolarization that progressed through the slice. The greatest change in mitochondrial potential occurred within the strata oriens, lucidum, and radiatum. For details, see the article by Bindokas et al., in this issue (pages 4570-4587).