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Cover picture: Recently, the rMAL cDNA has been cloned and been found to encode a new tetraspan protein expressed by oligodendrocytes and Schwann cells in central and peripheral myelin. MAL protein is detected in all myelinated areas of an adult rat cerebellum by immunocytochemistry with gold-coupled secondary antibodies and silver intensification on a free-floating section (top). Immunofluorescence with TRITC-labeled secondary antibodies outlines the presence of MAL protein on the apical membranes of cells in the P3 rat kidney collecting duct (bottom). The apical membranes of these cells as well as myelin membranes are known to be enriched in glycosphingolipids, which in turn are associated with the MAL protein. For details, see article by Frank et al. (in this issue, pages 4901-4913).