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Cover picture: Chemorepellants pattern innervation of the tongue. Dorsal views of the rat mandible at embryonic day 13 (E13) (top), E14 (middle), and E15 (bottom). At E13, two pairs of developing sensory nerves (brown) curve away from the anterior and lateral surface that will become the dorsal tongue. Beginning at E14, axons from both pairs of nerves are permitted to enter the lateral tongue but not the medial tongue. The medial progress of innervation corresponds to a progressive narrowing of a repellant influence centered around the anterior midline. Semaphorin III/D and neuropilin-1 are implicated at the predominant diffusible repellant and receptor, respectively. For details, see the article by Rochlin and Farbman in this issue (pages 6840-6852).
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