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Cover picture: Composite figure showing the squid Loligo pealei (top), a micrograph of a squid giant presynaptic axon microinjected with fluorescein-dextran (middle), and traces of simultaneous presynaptic and postsynaptic electrophysiological recordings obtained before, during, and after peptide injection (bottom, left). A squid member of the Sec1 family of vesicular trafficking proteins, s-Sec1, was cloned, and recombinant s-Sec1 and a deduced s-Sec1 peptide were microinjected directly into the giant nerve terminal. Both the recombinant protein (not shown) and the s-Sec1 peptide (bottom, left) inhibited transmitter release. Quantitative electron microscopic analysis performed on ultrathin sections taken throughout the terminal revealed that neither agent inhibited synaptic vesicle targeting to and docking at active zones of the presynaptic plasma membrane (bottom, right). For details, see the article by Dresbach et al., in this issue (pages 2923-2932).