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Cover Figure


Cover picture: Subsynaptic distribution of group I metabotropic glutamate receptors (mGluRs) in the globus pallidus in monkeys. A large biocytin-filled pallidal neuron is depicted with two insets showing group I mGluR immunogold labeling: 1, at the edges of an asymmetric postsynaptic specialization associated with a glutamatergic terminal from the subthalamic nucleus (dark green); and 2, in the main body of a symmetric postsynaptic specialization established by a GABAergic terminal from the striatum (light green). The schematic diagram at the bottom summarizes the subsynaptic distribution of group I mGluRs (red symbols) on a pallidal dendrite contacted by a glutamatergic bouton from the subthalamic nucleus (dark green) and a GABAergic terminal from the striatum (light green). In brief, group I mGluRs are found in the core of symmetric GABAergic synapses from the striatum or perisynaptic to asymmetric glutamatergic synapses from the subthalamic nucleus. A large density of mGluRs are also expressed extrasynaptically along pallidal dendrites. For details, see the article by Hanson and Smith, in this issue (pages 6488-6496).


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