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Cover picture: Confocal micrographs showing the localization of the AMPA receptor subunit GluR1 (red) compared with the synaptic marker SV2 (green) in control (top) and AMPA-pretreated (bottom) cultured hippocampal neurons. Within 15 min after application, AMPA (100 µM) caused GluR1 subunits to redistribute away from synaptic sites. This redistribution is indicated in the displayed micrographs by reduced GluR1 immunoreactivity associated with SV2-positive structures and a concomitant accumulation of GluR1 immunoreactivity in nonsynaptic regions and the cytoplasm of AMPA-pretreated cells (shown at higher magnification in the insets). Inhibition of miniature EPSCs measured in AMPA-pretreated cultures after washout, displayed in the overlayed electrophysiological tracings, suggests that the rapid redistribution of GluR1 subunits plays a functional role in regulating synaptic transmission. For details, see the article by Lissin et al., in this issue (pages 1263-1272). Illustration courtesy of Heather Deacon.