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Cover picture: A hippocampal neuron in culture comparing fluorescence localization of postsynaptic proteins and cytoskeletal components. The neuron was triple-labeled for tubulin (blue, antibody labeling), filamentous actin (red, phalloidin staining), and excitatory postsynaptic scaffolding proteins of the postsynaptic density 95 (PSD-95) family (green, antibody labeling). PSD-95 clusters at dendritic spines colocalizing with concentrations of filamentous actin (overlap appears yellow). Microtubules and lower concentrations of actin are present in dendrite and axon shafts. Cytoskeletal perturbation experiments showed that PSD-95 and associated proteins were maintained at synapses independently of filamentous actin and microtubules, whereas other components of spiny synapses, including Ca/calmodulin-dependent protein kinase II, were dependent on actin for postsynaptic localization. For details, see the article by Allison et al., in this issue (pages 4545-4554).