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Cover picture: Retention of polyneuronal innervation in muscle fibers whose newly formed motoneuronal inputs have been kept synchronously active for ~2 weeks in vivo. Bottom, Cross section of an adult rat soleus muscle reinnervated in an ectopic region by a transplanted foreign nerve, showing myofibers in red and foreign axons in green pseudocolors, after visualization with immunofluorescence (myofibers, primary anti-dystrophin, secondary TRITC-conjugated antibodies; axons, primary anti-neurofilament, secondary FITC-conjugated antibodies). Top left, Muscle steps of the endplate potential evoked by graded electrical stimulation of the muscle nerve by in vitro intracellular recording from a superficial myofiber under curare, indicating polyneuronal innervation. Note that the fibers close to the foreign nerve implant are bigger than the more distant ones, the latter being not yet reinnervated. In control preparations (data not shown), whose axons are asynchronously active, elimination of polyneuronal innervation has already taken place at this developmental stage. For details, see the article by Busetto et al., in this issue (pages 685-695).
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