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Cover picture: P2X₇ receptor subunit immunoreactivity (blue) was detected in mossy fiber terminals of the rat hippocampus. P2X₇ immunoreactivity was not colocalized with the dendritic marker MAP2 (green) but was colocalized with terminal marker syntaxin (see paper). Cell bodies were labeled with ethidium bromide (red). Activation of P2X₇ receptors with the agonist 2',3'-O-(4-benzoylbenzoyl)-ATP caused a long-lasting presynaptic inhibition of mossy fiber-CA3 synaptic transmission. This presynaptic form of mossy fiber depression was mediated by the activation of p38 MAP kinase. For details, see the article by Armstrong et al. in this issue (pages 5938-5945).