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Cover picture: Surface view of the three-dimensional morphology of the calyx of Held and its postsynaptic principal neuron reconstructed from serial ultrathin sections. They form a giant axosomatic synaptic structure (diameter, ~20 µm) in the medial nucleus of the trapezoid body of the rat brainstem. The calyx of Held (yellow) covers its postsynaptic target (transparent blue) like a cup with several finger-like stalks. Hundreds of membrane specializations (synaptic contacts in red and puncta adherentia in magenta) are distributed over the apposition zone (appearing in green, because we are looking through the transparent postsynaptic membrane) between the nerve terminal and its postsynaptic principal neuron. The nucleus of the postsynaptic neuron (brown) is located more toward the calyx. Reconstructions, data analysis, and visualizations were performed using CAR software (Contour Alignment Reconstruction; contact kurt.saetzler{at}iwr.uni-heidelberg.de.). For details, see the article by Sätzler et al. in this issue (pages 10567-10579).