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Cover Picture: In mixed glial cultures from mice lacking the toll-like receptor TLR4, microglia (stained with IB4, green) are present but unable to cause injury to oligodendrocytes (O4, red) in response to lipopolysaccharide. Nuclei are stained with DAPI (blue). For details, see the article by Lehnardt et al. in this issue (pages 2478-2486).