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Cover Figure


Cover picture: Fluorescence immunolocalization of the receptor for the class of migraine drugs known as the "triptans," serotonin 5-HT1D receptor (red) and substance P (green), a neurotransmitter associated with "pain"-responsive primary afferents, in rat dorsal root ganglia. Their colocalization has implications for the peripheral mechanism of action of the triptan drugs, not only in migraine but possibly also in other forms of pain. A nuclear counterstain (DAPI) is shown in blue and also labels nuclei in glia and connective tissue. For details, see the article by Potrebic et al. in this issue (pages 10963-10970).


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