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Cover picture: Isolated postsynaptic densities (PSDs) visualized by rotary-shadow electron microscopy. Viewed from its cleft surface (top), the PSD is studded with a flat layer of granular particles that coat a central filamentous mesh. PSDs were labeled with immunogold for CaMKII, which is restricted to the cytoplasmic surface of the PSD (bottom) but not the cleft surface (10 nm immunogold particles colored red). The cytoplasmic surface of the PSD is highly convoluted with protrusions of material extending from its central mesh, and most of the label for CaMKII is found on these protrusions. For details, see the article by Petersen et al. in this issue (pages 11270-11278).