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Cover picture: Syntaxin-1A is excluded from recycling synaptic vesicles. The image shows the distribution of syntaxin–pHluorin expressed in the axon of a hippocampal neuron in cell culture. Almost all of the syntaxin is found on the cell surface, and functional studies show that it is not internalized during synaptic vesicle recycling. For details, see the article by Mitchell and Ryan in this issue (pages 4884-4888).