About the Cover
Cover picture:
This confocal image shows area CA1
of an acute rat hippocampal slice that was fixed 60
min after the induction of late long-term potentiation
(LTP) by high-frequency stimulation delivered to the
Schaffer collaterals. Before stimulation, the distal
apical dendrites (located toward the bottom of the
image) had been isolated from the cell bodies by a cut
(horizontal black band). The slice was labeled for p70
S6 kinase (p70S6K) phosphorylated at T389 (red) and
elongation factor 1A (green). As described in the
accompanying paper, the LTP-associated increases in
the phosphorylation of p70S6K and in the expression
of elongation factor 1A in the isolated dendrites were
siimilar to those obtained in intact CA1 dendrites,
consistent with the local control of translation
through the mammalian target of rapamycin pathway
in LTP. For details, see the article by Tsokas et al. in
this issue (pages 5833-5843).
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Copyright © 2005 by Society for Neuroscience.
