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Cover legend: Cerebrovascular amyloid angiopathy (CAA)-affected vessel in the Tg2576 mouse model of amyloid deposition. Representative example of CAA in a vessel segment of a living Tg2576 mouse imaged with multiphoton microscopy. Vascular and parenchymal Aβ deposits are identified by fluorescence from systemically administered methoxy-XO4 (red pseudocolor). Fluorescent angiograms with Texas Red dextran were performed to identify fiduciary markers (blue pseudocolor). The serial imaging of individual segments of CAA-laden leptomeningeal vessels allowed detection of clearance of CAA after treatment with anti-Aβ antibody. For more information, see the article by Prada et al. in the February 21, 2007 issue (pages 1973–1980).

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