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Cover legend: An artistic rendering of optogenetic technologies in action. Blue and yellow lights can be used to evoke or inhibit electrical activity (represented by the intense glow in targeted neurons) in neurons. Illustration credit: Feng Zhang, Steve Dixon, Viviana Gradinaru, and Karl Deisseroth. For more information, see the article by Gradinaru et al. in this issue (pages 14231–14238).

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