The COMT val158met polymorphism and brain morphometry in healthy young adults
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Cited by (61)
Distribution, properties, and inhibitor sensitivity of zebrafish catechol-O-methyl transferases (COMT)
2017, Biochemical PharmacologyCross-species approaches to pathological gambling: A review targeting sex differences, adolescent vulnerability and ecological validity of research tools
2013, Neuroscience and Biobehavioral ReviewsCitation Excerpt :In addition to serotonin, dopamine (DA) is also strongly implicated in development of the brain and the transition from adolescence to adulthood. For instance, a significant effect of catechol-O-methyltransferase (COMT) genotype on age-related differences in grey and white matter density has been noted (Zinkstok et al., 2006). COMT is an enzyme active in the prefrontal cortex mediating the breakdown of dopamine.
The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity in patients with panic disorder
2013, Journal of Affective DisordersCitation Excerpt :In addition, a greater severity of total WM hyperintensity was associated with a diagnosis of panic disorder in a dose-dependent pattern (Bae et al., 2010). Furthermore, prior reports of WM abnormalities in relation to COMT have proposed that regional differences in FA values (Sundram et al., 2010; Thomason et al., 2010) and density (van Amelsvoort et al., 2008; Zinkstok et al., 2006) could be associated with variation in COMT genotypes. Considering the probable genetic influence of COMT on the pathogenesis of panic disorder and WM connectivity together, this study for the first time investigated WM connectivity using diffusion tensor imaging in relation to the COMT val158met variant in panic disorder.
Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls
2011, NeuroImageCitation Excerpt :These relationships are particularly prominent in fronto-temporal cortical regions that are relevant to the neurobiology of schizophrenia [e.g. dlPFC, medPFC, cingulate and STS (Ellison-Wright and Bullmore, 2010)], and sub-serve cognitive tasks which tap DA-sensitive aspects of prefrontal information processing such as working memory (Mattay et al., 2003). Other structural neuroimaging studies in HCs have also found anatomical differences in similar fronto-temporal regions as a function of Val158Met genotype (Cerasa et al., 2010; Honea et al., 2009; Zinkstok et al., 2006). These cross-sectional studies all examine older samples than ours, and almost all (Cerasa et al., 2010) focus on cortical volume rather than CT.