PT  - JOURNAL ARTICLE
AU  - A Linacre
AU  - E Kellett
AU  - S Saunders
AU  - K Bright
AU  - PR Benjamin
AU  - JF Burke
TI  - Cardioactive neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) and novel related peptides are encoded in multiple copies by a single gene in the snail Lymnaea stagnalis
AID  - 10.1523/JNEUROSCI.10-02-00412.1990
DP  - 1990 Feb 01
TA  - The Journal of Neuroscience
PG  - 412--419
VI  - 10
IP  - 2
4099  - http://www.jneurosci.org/content/10/2/412.short
4100  - http://www.jneurosci.org/content/10/2/412.full
SO  - J. Neurosci.1990 Feb 01; 10
AB  - The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) is a potent cardioactive neuropeptide in Lymnaea stagnalis. Isolation and sequencing of 2 cDNAs and a genomic clone shows that a single gene encodes a precursor protein which contains 9 copies of the FMRFamide peptide, 2 copies of the related peptide Phe-Leu-Arg-Phe-NH2 (FLRFamide), and single copies of the putative pentapeptides Gln-Phe- Tyr-Arg-lle-NH2 (posttranslationally modified to pQFYRlamide) and Glu- Phe-Leu-Arg-lle-NH2 (EFLRlamide). The gene is transcribed in the CNS and gives rise to a single RNA of 1.7 kb in size. The organization of the Lymnaea gene is significant with respect to the evolution of FMRFamide and related peptides in other organisms.