TY - JOUR T1 - Synaptic actions of identified peptidergic neuron R15 in Aplysia. III. Activation of the large hermaphroditic duct JF - The Journal of Neuroscience JO - J. Neurosci. SP - 1282 LP - 1290 DO - 10.1523/JNEUROSCI.11-05-01282.1991 VL - 11 IS - 5 AU - A Alevizos AU - KR Weiss AU - J Koester Y1 - 1991/05/01 UR - http://www.jneurosci.org/content/11/5/1282.abstract N2 - The purpose of the study described in this and the preceding two companion papers was to determine the synaptic actions of neuron R15, an endogenously bursting neurosecretory cell in Aplysia, as a step toward determining its physiological function. The results described in this paper demonstrate that activity in R15 activates anterograde peristaltic movements in the segment of the large hermaphroditic duct through which eggs move during egg-laying behavior. This action is mimicked by R15 alpha 1 peptide, a putative transmitter of R15. The neuroendocrine bag cells, which initiate egg laying when they fire in a population burst, have been shown by others to excite R15. Our data suggest that R15 mediates excitatory effects of the bag cells on the large hermaphroditic duct. Taken with the results of the two companion papers, these data support the hypothesis that R15 integrates various aspects of egg-laying behavior. The desensitization of R15's postsynaptic actions may complement the long-lasting refractoriness of the bag cells described by others, with both effects contributing to the episodic nature of egg laying. ER -