PT - JOURNAL ARTICLE AU - RE Marc AU - DM Lam TI - Glycinergic pathways in the goldfish retina AID - 10.1523/JNEUROSCI.01-02-00152.1981 DP - 1981 Feb 01 TA - The Journal of Neuroscience PG - 152--165 VI - 1 IP - 2 4099 - http://www.jneurosci.org/content/1/2/152.short 4100 - http://www.jneurosci.org/content/1/2/152.full SO - J. Neurosci.1981 Feb 01; 1 AB - Autoradiographic localization of high affinity [3H]glycine uptake in the retina of the goldfish has been used to study some anatomical and physiological properties of potentially glycinergic neurons. There are two classes of retinal cells exhibiting high affinity glycine uptake: Aa amacrine cells and I2 interplexiform cells. Aa amacrine cells constitute about 20% of the somas in the amacrine cell layer and send their dendrites to the middle of the inner plexiform layer. There they are both pre- and postsynaptic primarily to other amacrine cells. Photic modulation of glycine uptake indicates that they are probably red-hyperpolarizing/green-depolarizing neurons. I2 interplexiform cells are a newly discovered type of interplexiform cell; in the outer plexiform layer, they receive direct synaptic input from the somas of red-dominated GABAergic H1 horizontal cells and are apparently presynaptic to dendrites of unidentified types of horizontal cells. The connections of I2 interplexiform cells have not been successfully characterized in the inner plexiform layer. These findings extend our knowledge of neurochemically specific pathways in the cyprinid retina and indicate that glycine, like GABA, is a neurotransmitter primarily involved with circuits coding “red” information.